Laser-Tissue Interactions – Biophotonics Applications
Abstract: The field of biophotonics is a highly cross-disciplinary science and technology platform merging life sciences, physics, and engineering. Here are three research projects that are described in the field of biophotonics. The first project builds upon optical nerve stimulation (ONS) technique. This technique, using infrared laser energy, has been developed recently as a potential alternative to conventional electrical nerve stimulation. More recently, the ability of ONS in pre-clinical studies as an intra-operative diagnostic method for identifying the prostate Cavernous nerves has been demonstrated in in-vivo rat studies. The second project is expansions of recently developed dispersion-based swept-wavelength laser source for 4D Doppler optical coherence tomography (OCT). Current OCT systems are able to provide inter-frame angiographic imaging and also require the use of highly accurate triggering hardware or implementation of post-processing phase calibration algorithms. The presented angiographic system is comprised from a novel 18.9 MHz swept wavelength source integrated with a MEMs-based 23.7 kHz fast-axis scanner. The system provides rapid acquisition of frames and volumes on which a range of Doppler and intensity-based angiographic analyses can be performed. Interestingly, the source and 1.8 Gigasample per sec acquisition card can be directly phase-locked to provide an intrinsically phase stable imaging system supporting volumetric Doppler measurements without the need for individual A-line triggers or post-processing phase calibration algorithms. The third project is to develop a method using novel apparatus for treatment of Barrett’s esophagus, which is a precancerous condition of esophagus and associated with esophageal cancer (adenocarcinoma of esophagus). At the point of care, there is a need for a device that enables a single-session and minimally destructive tissue damage in endoscopic mucosal treatment of Barrett’s esophagus over large areas. The primary objective of the project is to configure a prototype endoscopic mucosal ablation device that ablate (damage) the mucosa layer of the esophagus to a depth sufficient to eliminate the lesion, but not sufficient deep to induce residual thermal effects within the deeper tissue layers.
Reminder: Tea and cookies will be in the seminar room before the seminar.